Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation
نویسندگان
چکیده
منابع مشابه
Interleukin-6 receptor antibody enhances the efficacy of cyclooxygenase-2 inhibitor to suppress human cholangiocarcinoma cell proliferation and invasion
Cyclooxygenase-2 (COX-2) plays an important role in Cholangiocarcinoma (CCA). Therefore, targeting COX-2 alone or in combination with other therapeutic agents may be a potential new effective treatment for patients with CCA. This study aimed to investigate whether Interleukin-6 (IL-6) receptor antibody could enhance the inhibitory effects of NS-398, a selective COX-2 inhibitor, on CCA cell prol...
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It is well admitted that the link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways, which act during the different steps of tumorigenesis. The cyclooxygenases (COXs) are a family of enzymes, which catalyze the rate-limiting step of prostaglandin biosynthesis. This family contains three members: ubiquitously expressed COX-1, which is involved in h...
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Background: The role of cyclooxygenase-2 (COX-2) overexpression in colorectal cancers has engaged interest in the role of COX-2 and prostaglandin E2 (PGE2) in cancer cell mitogenesis. Amphiregulin (AR), an epidermal growth factor receptor (EGFR) ligand, has been directly related to PGE2, which activates the AR promoter, causing increased AR expression. Aims: To identify if COX-2 and AR play a r...
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Limited or regulatory proteolysis plays a critical role in many important biological pathways like blood coagulation, cell proliferation, and apoptosis. A better understanding of mechanisms that control this process is required for discovering new proteolytic events and for developing inhibitors with potential therapeutic value. Two features that determine the susceptibility of peptide bonds to...
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Introduction: Previous investigations have indicated that the presence of BIO (6-Bromoindirubin-3-Oxime) in medium of some cell culture enhances the cell proliferation and viability. The aim of the present study was to investigate the BIO effects on in vitro expansion of rat marrow-derived mesenchymal stem cells (MSCs) culture. Methods: In the present experimental study, bone marrow cells from ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21093195